Postdoctoral Fellow-MSH-30020-176

Dubois Laboratory — Icahn School of Medicine at Mount Sinai

Additional Ventures Cures Collaborative

The Scientific and Clinical Context

Single ventricle (SV) heart disease encompasses a spectrum of severe congenital cardiac malformations - including hypoplastic left heart syndrome (HLHS) and heterotaxy - in which one ventricular chamber is absent, rudimentary, or unable to sustain adequate systemic or pulmonary circulation. Affecting approximately 1 in 5,000 live births, single ventricle disease remains one of the most challenging and life-limiting forms of congenital heart disease. Current management relies on a series of palliative surgeries culminating in the Fontan circulation, a non-physiological arrangement that places the single ventricle under chronic pressure and volume stress. Despite improvements in surgical outcomes, patients face a lifetime of cardiovascular complications, progressive ventricular failure, and significantly reduced life expectancy.